Journal article
Don't it make your brown eyes blue? A comparison of iris colour across latitude in Australian twins
PG Sanfilippo, CH Wilkinson, JB Ruddle, G Zhu, NG Martin, AW Hewitt, DA Mackey
Clinical and Experimental Optometry | WILEY-BLACKWELL | Published : 2015
DOI: 10.1111/cxo.12209
Abstract
Background: The aim was to determine whether latitudinal (Queensland versus Tasmania) variation in reported disease frequency in Australia may be biased by differences in population. Methods: A retrospective analysis was conducted from data of two large Australian twin studies (n = 1,835) having undertaken ophthalmic examination, namely, Twins Eye Study in Tasmania (TEST) and the Brisbane Adolescent Twins Study (BATS). Ordinal logistic regression was used to compute odds ratios and predicted probabilities for each category of eye colour by state. Results: Tasmanian residence was associated with lower odds of darker iris colour (odds ratio 0.77, 95% CI [0.63-0.95]) signifying that participant..
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Awarded by NHMRC, Canberra Australia
Funding Acknowledgements
The Australian Twin Registry is supported by a National Health and Medical Research Council (NHMRC) Enabling Grant (2004-2009). We also thank the following organisations for their financial support: Clifford Craig Medical Research Trust, Ophthalmic Research Institute of Australia (ORIA), Peggy and Leslie Cranbourne Foundation, NHMRC, Canberra Australia (Project Grant 350415), National Health and Medical Research Foundation Project Grant (2005-2007), Jack Brockhoff Foundation, NEI Project Grant (2007-2010) and the American Health Assistance Foundation (AHAF). Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government. DA Mackey was the recipient of the Pfizer Australia Senior Research Fellowship. We thank all study participants, and their families for participating in this project.