Journal article
Persistence of neisseria gonorrhoeae DNA following treatment for pharyngeal and rectal gonorrhea is influenced by antibiotic susceptibility and reinfection
M Bissessor, DM Whiley, CK Fairley, CS Bradshaw, DM Lee, AS Snow, MM Lahra, JS Hocking, MY Chen
Clinical Infectious Diseases | Published : 2015
DOI: 10.1093/cid/ciu873
Abstract
Background.To guide interpretation of gonorrhea tests of cure using nucleic acid amplification testing, this study examined the persistence of Neisseria gonorrhoeae DNA following treatment for pharyngeal and rectal gonorrhea. Methods.Men who had sex with men diagnosed with pharyngeal or rectal gonorrhea underwent swabbing from the pharynx or rectum 7 and 14 days following treatment. Repeat testing for N. gonorrhoeae was undertaken using real-time polymerase chain reaction (PCR) assays targeting the opa gene and porA pseudogene. Results.One hundred pharyngeal and 100 rectal gonorrhea infections in 190 men were included. For pharyngeal gonorrhea, positivity of N. gonorrhoeae DNA on both PCR as..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
M. B. was supported by a National Health and Medical Research Council postgraduate scholarship (ID 1038734).