Mold-Templated Inorganic-Organic Hybrid Supraparticles for Code livery of Drugs

James W Maina; Jiwei Cui; Mattias Bjoernmalm; Andrew K Wise; Robert K Shepherd; Frank Caruso

Journal article

Mold-Templated Inorganic-Organic Hybrid Supraparticles for Code livery of Drugs

James W Maina, Jiwei Cui, Mattias Bjoernmalm, Andrew K Wise, Robert K Shepherd, Frank Caruso

BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2014

DOI: 10.1021/bm501171j

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Abstract

This paper reports a facile and robust mold-templated technique for the assembly of mesoporous silica (MS) supraparticles and demonstrates their potential as vehicles for codelivery of brain-derived neurotrophic factor (BDNF) and dexamethasone (DEX). The MS supraparticles are assembled using gelatin as a biodegradable adhesive to bind and cross-link the particles. Microfabricated molds made of polydimethylsiloxane are used to control the size and shape of the supraparticles. The obtained mesoporous silica-gelatin hybrid supraparticles (MSG-SPs) are stable in water as well as in organic solvents, such as dimethyl sulfoxide, and efficiently coencapsulate both BDNF and DEX. The MSG-SPs also exh..

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University of Melbourne Researchers

Robert Shepherd Author Medical Bionics Department

Andrew Wise Author Medical Bionics Department

Frank Caruso Author Chemical Engineering

Jiwei Cui Author Chemical Engineering

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Awarded by Australian Research Council (ARC)

Awarded by National Health and Medical Research Council

Awarded by ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

Funding Acknowledgements

This work was supported by the Australian Research Council (ARC) under the Australian Laureate Fellowship (F.C, FL120100030) and the Super Science Fellowship (F.C., FS110200025) schemes, and the National Health and Medical Research Council (A.K.W., R.K.S., F.C, APP1005071 and APP1064375), as well as the Australian Government through an Australian Postgraduate Award (M.B.). This research was also conducted and funded by the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (Project Number CE140100036). This work was performed in part at the Melbourne Centre for Nanofabrication in the Victorian Node of the Australian National Fabrication Facility and at the Melbourne Characterisation and Fabrication Platform at The University of Melbourne. The Bionics Institute acknowledges funding from the Victorian Government's Operational Infrastructure Support Program.