Journal article
Modelling extracellular electrical stimulation: part 3. Derivation and interpretation of neural tissue equations
H Meffin, B Tahayori, EN Sergeev, IMY Mareels, DB Grayden, AN Burkitt
Journal of Neural Engineering | IOP Publishing | Published : 2014
Abstract
Objective. A common approach in modelling extracellular electrical stimulation is to represent neural tissue by a volume conductor when calculating the activating function as the driving term in a cable equation for the membrane potential. This approach ignores the cellular composition of tissue, including the neurites and their combined effect on the extracellular potential. This has a number of undesirable consequences. First, the two natural and equally valid choices of boundary conditions for the cable equation (i.e. using either voltage or current) lead to two mutually inconsistent predictions of the membrane potential. Second, the spatio-temporal distribution of the extracellular poten..
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Grants
Awarded by Australian Research Council (ARC) through its Special Research Initiative (SRI) in Bionic Vision Science and Technology grant
Awarded by Victorian Life Sciences Computation Initiative (VLSCI) grant
Funding Acknowledgements
This research was supported by the Australian Research Council (ARC) through its Special Research Initiative (SRI) in Bionic Vision Science and Technology grant to Bionic Vision Australia (BVA) SR1000005. The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program. This research was supported by a Victorian Life Sciences Computation Initiative (VLSCI) grant number VR0138 on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government.