Modelling extracellular electrical stimulation: part 4. Effect of the cellular composition of neural tissue on its spatio-temporal filtering properties

Abstract

Objective. The objective of this paper is to present a concrete application of the cellular composite model for calculating the membrane potential, described in an accompanying paper. Approach. A composite model that is used to determine the membrane potential for both longitudinal and transverse modes of stimulation is demonstrated. Main results. Two extreme limits of the model, near-field and far-field for an electrode close to or distant from a neuron, respectively, are derived in this paper. Results for typical neural tissue are compared using the composite, near-field and far-field models as well as the standard isotropic volume conductor model. The self-consistency of the composite mod..