Development and Validation of a Risk Score Predicting Risk of Colorectal Cancer
Annika Steffen, Robert J MacInnis, Grace Joshy, Graham G Giles, Emily Banks, David Roder
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | AMER ASSOC CANCER RESEARCH | Published : 2014
BACKGROUND: Quantifying the risk of colorectal cancer for individuals is likely to be useful for health service provision. Our aim was to develop and externally validate a prediction model to predict 5-year colorectal cancer risk. METHODS: We used proportional hazards regression to develop the model based on established personal and lifestyle colorectal cancer risk factors using data from 197,874 individuals from the 45 and Up Study, Australia. We subsequently validated the model using 24,233 participants from the Melbourne Collaborative Cohort Study (MCCS). RESULTS: A total of 1,103 and 224 cases of colorectal cancer were diagnosed in the development and validation sample, respectively. Our..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Grant Support This research was completed using data collected through the 45 and Up Study (www.saxinstitute.org.au). The 45 and Up Study is managed by the Sax Institute in collaboration with major partner Cancer Council NSW; and partners: the National Heart Foundation of Australia (NSW Division); NSW Ministry of Health; beyondblue; Ageing, Disability, and Home Care, Department of Family and Community Services; the Australian Red Cross Blood Service; and UnitingCare Ageing.This work was supported by infrastructure from the Cancer Council Victoria and grants from the National Health and Medical Research Council of Australia 209057 and 251533.A. Steffen was supported by a scholarship from the German Research Foundation (DFG). E. Banks is supported by the National Health and Medical Research Council of Australia.