Mapping the relationship between subgenual cingulate cortex functional connectivity and depressive symptoms across adolescence

C Strikwerda-Brown; CG Davey; S Whittle; NB Allen; ML Byrne; OS Schwartz; JG Simmons; D Dwyer; BJ Harrison

Journal article

Mapping the relationship between subgenual cingulate cortex functional connectivity and depressive symptoms across adolescence

C Strikwerda-Brown, CG Davey, S Whittle, NB Allen, ML Byrne, OS Schwartz, JG Simmons, D Dwyer, BJ Harrison

Social Cognitive and Affective Neuroscience | Published : 2015

DOI: 10.1093/scan/nsu143

Abstract

Changes in the functional connectivity of the subgenual anterior cingulate cortex (SGC) have been linked with depressive symptoms. The aim of this study was to map this relationship across mid to late adolescence. Employing a longitudinal functional magnetic resonance imaging (fMRI) design, associations between patterns of resting-state SGC functional connectivity and symptoms of depression were examined at two time points in an initial sample of 72 adolescents. Using a region-of-interest approach, these associations were evaluated cross-sectionally and longitudinally. Cross-sectionally, weaker SGC functional connectivity with the posterior cingulate cortex (PCC), angular gyrus and dorsal pr..

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University of Melbourne Researchers

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Grants

Awarded by National Health and Medical Research Council

Awarded by Australian Research Council

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was supported by grants from the Colonial Foundation, the National Health and Medical Research Council (program grant 350241, career development fellowship 1061757 to C.G.D. and 1007716 to S.W., clinical career development award 628509 to B.J.H.) and the Australian Research Council (discovery grant DP0878136, DP1092637).