Journal article

Perioperative Aspirin and Clonidine and Risk of Acute Kidney Injury A Randomized Clinical Trial

Amit X Garg, Andrea Kurz, Daniel I Sessler, Meaghan Cuerden, Andrea Robinson, Marko Mrkobrada, Chirag R Parikh, Richard Mizera, Philip M Jones, Maria Tiboni, Adria Font, Virginia Cegarra, Maria Fernanda Rojas Gomez, Christian S Meyhoff, Tomas VanHelder, Matthew TV Chan, David Torres, Joel Parlow, Miriam de Nadal Clanchet, Mohammed Amir Show all

JAMA | AMER MEDICAL ASSOC | Published : 2014


IMPORTANCE: Acute kidney injury, a common complication of surgery, is associated with poor outcomes and high health care costs. Some studies suggest aspirin or clonidine administered during the perioperative period reduces the risk of acute kidney injury; however, these effects are uncertain and each intervention has the potential for harm. OBJECTIVE: To determine whether aspirin compared with placebo, and clonidine compared with placebo, alters the risk of perioperative acute kidney injury. DESIGN, SETTING, AND PARTICIPANTS: A 2 × 2 factorial randomized, blinded, clinical trial of 6905 patients undergoing noncardiac surgery from 88 centers in 22 countries with consecutive patients enrolled ..

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University of Melbourne Researchers


Funding Acknowledgements

The Perioperative Ischemic Evaluation-2 (POISE-2) Trial and this acute kidney injury substudy were financially supported by grants from the Canadian Institutes of Health Research. Financial support for POISE-2 was also provided by the Australian National Health and Medical Research Council and the Spanish Ministry of Health and Social Policy. Boehringer Ingelheim provided the clonidine study drug and some funding. Bayer Pharma AG provided the aspirin study drug.