Journal article
Cellular requirements for systemic control of Salmonella enterica serovar Typhimurium infections in mice
A Kupz, S Bedoui, RA Strugnell
Infection and Immunity | Published : 2014
DOI: 10.1128/IAI.02192-14
Abstract
The rational design of vaccines requires an understanding of the contributions of individual immune cell subsets to immunity. With this understanding, targeted vaccine delivery approaches and adjuvants can be developed to maximize vaccine efficiency and to minimize side effects (S. H. E. Kaufmann et al., Immunity 33:555-577, 2010; T. Ben-Yedidia and R. Arnon, Hum. Vaccines 1:95-101, 2005). We have addressed the contributions of different immune cell subsets and their ability to contribute to the control and clearance of the facultative intracellular pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) in a murine model. Using a systematic and reproducible model of experimental a..
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Grants
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by NH&MRC Career Development Award
Awarded by NH&MRC CJ Martin Biomedical Early Career Fellowship
Funding Acknowledgements
Our research was supported by the National Health and Medical Research Council of Australia (NH & MRC; program grant: Fighting Infection, Exploiting Host-Pathogen Interactions [APP606788]). S.B. was a recipient of an NH&MRC Career Development Award (APP628464). A.K. is the recipient of an NH&MRC CJ Martin Biomedical Early Career Fellowship (APP1052764).