Inflammation Conditions Mature Dendritic Cells To Retain the Capacity To Present New Antigens but with Altered Cytokine Secretion Function
Javier Vega-Ramos, Antoine Roquilly, Yifan Zhan, Louise J Young, Justine D Mintern, Jose A Villadangos
JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2014
Dendritic cells (DCs) are directly activated by pathogen-associated molecular patterns (PAMPs) and undergo maturation. Mature DCs express high levels of MHC class II molecules ("signal 1"), upregulate T cell costimulatory receptors ("signal 2"), and secrete "signal 3" cytokines (e.g., IL-12). Mature DCs efficiently present Ags linked to the activating PAMP and prime naive T cells. However, mature DCs downregulate MHC II synthesis, which prevents them from presenting newly encountered Ags. DCs can also be indirectly activated by inflammatory mediators released during infection (e.g., IFN). Indirectly activated DCs mature but do not present pathogen Ags (as they have not encountered the pathog..View full abstract
This work was supported by funds from the National Health and Medical Research Council of Australia, the Fundacio Pedro I Pons (to J.V.-R.), the Societe Francaise d' Anesthesie Reanimation (to A.R.), and the Fondation des "Gueules Cassees" (to A.R.).