Journal article

Differences in hormone localisation patterns of K and L type enteroendocrine cells in the mouse and pig small intestine and colon

Hyun-Jung Cho, Samin Kosari, Billie Hunne, Brid Callaghan, Leni R Rivera, David M Bravo, John B Furness

Cell and Tissue Research | SPRINGER | Published : 2015

Abstract

This study has investigated the patterns of colocalisation of the conventional K cell marker, glucagon-like insulinotropic peptide (GIP), and the L cell markers, glucagon like peptide-1 (GLP-1) and peptide YY (PYY), in enteroendocrine cells (EEC) of the small intestine and colon of mouse and pig. All combinations of the hormones, 3 in a cell, 2 in a cell and 1 at a time, were encountered. In both species, the three most common EEC types contained (1) both GLP-1 and PYY but not GIP, (2) GLP-1 alone or (3) GIP plus GLP-1 without PYY. Few GIP plus PYY cells and rare cells containing all 3 hormones were encountered. Gradients of cell types occurred along the intestine. For example, in mouse, the..

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Grants

Funding Acknowledgements

This work was supported by funding from Pancosma, SA. We thank Professor Frank Dunshea and Maree Cox of the Faculty of Veterinary and Agricultural Sciences for supplying intestinal samples from pigs. We utilised facilities of the Australian Phenomics Network Histopathology and Organ Pathology Service, University of Melbourne.