Journal article
Exercise reduces infarct volume and facilitates neurobehavioral recovery: Results from a systematic review and meta-analysis of exercise in experimental models of focal ischemia
KJ Egan, H Janssen, ES Sena, L Longley, S Speare, DW Howells, NJ Spratt, MR Macleod, GE Mead, J Bernhardt
Neurorehabilitation and Neural Repair | Published : 2014
Abstract
Background. Regular exercise reduces the risk of a first-ever stroke and is associated with smaller infarcts. Although evidence has suggested that therapeutic exercise following stroke is beneficial, we do not yet know whether exercise reduces stroke severity and improves functional recovery. The mechanisms underlying any benefit remain unclear.Objective. To conduct a systematic review and meta-analysis of studies testing exercise in animal models of ischemic stroke where outcomes were measured as infarct volume, neurobehavioral score, neurogenesis, or a combination of these. We also sought evidence of publication bias.Methods. We searched 3 online databases for publications reporting the us..
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Awarded by Medical Research Council
Funding Acknowledgements
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: KE and MM are supported by the MRC Trials Methodology Hub. NS was supported by an Australian NHMRC career development fellowship (APP1035465). HJ was supported by a Postgraduate Scholarship from the National Heart Foundation, Australia and the Emlyn and Jennie Thomas Post Graduate Medical Research Scholarship. LL was supported by a PhD studentship from The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative (G0700704). Funding from the Biotechnology and Biological Sciences Research Council (BBSRC), Engineering and Physical Sciences Research Council (EPSRC), Economic and Social Research Council (ESRC), and Medical Research Council (MRC) is gratefully acknowledged.