Journal article

The prevention and management of infections due to multidrug resistant organisms in haematology patients

Jason A Trubiano, Leon J Worth, Karin A Thursky, Monica A Slavin

British Journal of Clinical Pharmacology | WILEY | Published : 2015

Abstract

Infections due to resistant and multidrug resistant (MDR) organisms in haematology patients and haematopoietic stem cell transplant recipients are an increasingly complex problem of global concern. We outline the burden of illness and epidemiology of resistant organisms such as gram-negative pathogens, vancomycin-resistant Enterococcus faecium (VRE), and Clostridium difficile in haematology cohorts. Intervention strategies aimed at reducing the impact of these organisms are reviewed: infection prevention programmes, screening and fluoroquinolone prophylaxis. The role of newer therapies (e.g. linezolid, daptomycin and tigecycline) for treatment of resistant and MDR organisms in haematology po..

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