Journal article
Attribution of 12 high-risk human papillomavirus genotypes to infection and cervical disease
EA Joura, KA Ault, FX Bosch, D Brown, J Cuzick, D Ferris, SM Garland, AR Giuliano, M Hernandez-Avila, W Huh, OE Iversen, SK Kjaer, J Luna, D Miller, J Monsonego, N Munoz, E Myers, J Paavonen, P Pitisuttithum, M Steben Show all
Cancer Epidemiology Biomarkers and Prevention | Published : 2014
Abstract
Background: We estimated the prevalence and incidence of 14 human papillomavirus (HPV) types (6/11/ 16/18/31/33/35/39/45/51/52/56/58/59) in cervicovaginal swabs, and the attribution of these HPV types in cervical intraepithelial neoplasia (CIN), and adenocarcinoma in situ (AIS), using predefined algorithms that adjusted for multiple-type infected lesions. Methods: A total of 10,656 women ages 15 to 26 years and 1,858 women ages 24 to 45 years were enrolled in the placebo arms of one of three clinical trials of a quadrivalent HPV vaccine. We estimated the cumulative incidence of persistent infection and the proportion of CIN/AIS attributable to individual carcinogenic HPV genotypes, as well a..
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Funding Acknowledgements
This study was supported by Merck and Co.