Journal article
The effects of plasmalyte-148 vs. Hartmann's solution during major liver resection: A multicentre, double-blind, randomized controlled trial
L Weinberg, B Pearce, R Sullivan, L Siu, N Scurrah, C Tan, M Backstrom, M Nikfarjam, L Mcnicol, D Story, C Christophi, R Bellomo
Minerva Anestesiologica | EDIZIONI MINERVA MEDICA | Published : 2015
Abstract
Background. The acid-base, biochemical and hematological effects of crystalloid solutions have not been comprehensively evaluated in patients with liver resection. Methods. Design: multicenter, prospective, double-blind randomized controlled trial investigating the biochemical effects of Hartmann's solution (HS) or Plasmalyte-148 (PL) in 60 patients undergoing major liver resection. Primary outcome: base excess immediately after surgery. Secondary outcomes: changes in blood biochemistry and hematology. Results. At completion of surgery, patients receiving HS had equivalent mean standard base excess (-1.7±2.2 vs. -0.9±2.3 meq/L; P=0.17) to those treated with PL. However, patients treated with..
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Funding Acknowledgements
Baxter Healthcare provided an unrestricted grant to fund this multicenter research trial and supplied all the blinded trial fluid. This study conception, design, trial management, data collection, data analyses, and the writing of the manuscript, have been executed completely independently of Baxter Healthcare and any other external organizations.