Journal article
Exploring the role of endothelium in the tumour response to anti-angiogenic therapy
YC He, MM Halford, MG Achen, SA Stacker
Biochemical Society Transactions | PORTLAND PRESS LTD | Published : 2014
DOI: 10.1042/BST20140173
Abstract
A chronic hyperactivated angiogenic state in cancer plays an important role in tumour growth and metastasis and has been identified as one of the hallmarks of cancer. Inhibition of this process has been associated with tumour suppression in many pre-clinical contexts using different animal tumour models. Anti-angiogenic therapeutics were subsequently developed and used to treat several prevalent types of human cancer. However, recent clinical experience has revealed limitations of this approach in treating cancer as patient response varies over a wide range. Given that there are complex underlying molecular and cellular changes provoked by anti-angiogenic treatment within the tumour microenv..
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Funding Acknowledgements
S.A.S. and M.G.A. are supported by Project Grants, Research Fellowships and a Programme Grant from the National Health and Medical Research Council of Australia (NHMRC), and by funds from the Operational Infrastructure Support Program provided by the Victorian Government, Australia. Y.-C.H. is supported by a Melbourne International Fee Remission Scholarship (MIFRS) and a Melbourne International Research Scholarship (MIRS) from the University of Melbourne, Australia.