Sex steroids levels in chronic kidney disease and kidney transplant recipients: associations with disease severity and prediction of mortality
Mathis Grossmann, Rudolf Hoermann, Mark Ng Tang Fui, Jeffrey D Zajac, Franscesco L Ierino, Matthew A Roberts
CLINICAL ENDOCRINOLOGY | WILEY | Published : 2015
OBJECTIVE: Our objective was to characterize and evaluate prognostic implications of circulating sex steroids in patients at different stages of chronic kidney disease (CKD). DESIGN: Prospective observational cohort study. PATIENTS: We prospectively recruited patients with CKD III-IV, undergoing chronic dialysis and kidney transplant recipients (KTR) from a single centre in 2003-2004. MEASUREMENTS: Two stored samples taken 3 months apart were analysed for sex hormones using liquid chromatography/tandem mass spectrometry, and the mean of the two was used for analysis. We also measured novel biomarkers troponin T and NT-proBNP. Patients were followed until death, transplant or 30 June 2013, an..View full abstract
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Awarded by National Health and Medical Research Council of Australia Career Development Fellowship
M Grossmann was supported by a National Health and Medical Research Council of Australia Career Development Fellowship (# 1024139). The authors thank Professor David Power, Department of Nephrology, Austin Health, for contributing Research funds to perform the sex hormone assays in this study.