Journal article
IGFBP-2 inhibits adipogenesis and lipogenesis in human visceral, but not subcutaneous, adipocytes
SW Yau, VC Russo, IJ Clarke, FR Dunshea, GA Werther, MA Sabin
International Journal of Obesity | Published : 2015
DOI: 10.1038/ijo.2014.192
Abstract
IGF-binding protein (IGFBP)-2 is the principal IGFBP produced by white adipocytes during adipogenesis, and circulating levels are reduced in obesity. Overexpression of IGFBP-2 in transgenic mice prevents obesity, but depot-specific effects of IGFBP-2 on adipo/lipogenesis are unknown. The present study aimed to investigate whether IGFBP-2 affects adipo/lipogenesis in a depot-specific manner and explore potential mechanisms.Methods:Following adipocyte characterisation, IGFBP-2 levels were measured from human subcutaneous and visceral preadipocytes, and IGFBP-2 dose-responses were then undertaken with exogenous IGFBP-2 in an in vitro IGF-I-free system to examine adipo/lipogenesis. Following thi..
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Awarded by Murdoch Children's Research Institute
Funding Acknowledgements
This work was supported by Murdoch Childrens Research Institute. Authors from the Murdoch Childrens Research Institute are supported in part by the Victorian Government Operational Infrastructure Support Program. MAS is supported through a National Health and Medical Research Council Professional Training Fellowship APP1012201. SWY is a recipient of an Australian Postgraduate Award scholarship.