Journal article

Validity of Acute Stroke Lesion Volume Estimation by Diffusion-Weighted Imaging-Alberta Stroke Program Early Computed Tomographic Score Depends on Lesion Location in 496 Patients With Middle Cerebral Artery Stroke

Julian Schroeder, Bastian Cheng, Martin Ebinger, Martin Koehrmann, Ona Wu, Dong-Wha Kang, David S Liebeskind, Thomas Tourdias, Oliver C Singer, Soren Christensen, Bruce Campbell, Marie Luby, Steven Warach, Jens Fiehler, Jochen B Fiebach, Christian Gerloff, Goetz Thomalla

Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014

Abstract

BACKGROUND AND PURPOSE: Alberta Stroke Program Early Computed Tomographic Score (ASPECTS) has been used to estimate diffusion-weighted imaging (DWI) lesion volume in acute stroke. We aimed to assess correlations of DWI-ASPECTS with lesion volume in different middle cerebral artery (MCA) subregions and reproduce existing ASPECTS thresholds of a malignant profile defined by lesion volume ≥100 mL. METHODS: We analyzed data of patients with MCA stroke from a prospective observational study of DWI and fluid-attenuated inversion recovery in acute stroke. DWI-ASPECTS and lesion volume were calculated. The population was divided into subgroups based on lesion localization (superficial MCA territory,..

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