Journal article
Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival
M Johansson, A Fanidi, DC Muller, JK Bassett, Ø Midttun, SE Vollset, RC Travis, D Palli, A Mattiello, S Sieri, A Trichopoulou, P Lagiou, D Trichopoulos, B Ljungberg, G Hallmans, E Weiderpass, G Skeie, CA González, M Dorronsoro, PH Peeters Show all
Journal of the National Cancer Institute | Published : 2014
DOI: 10.1093/jnci/dju327
Abstract
Background The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival. Methods The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants with blood samples between 1992 and 2000, and this analysis included 556 RCC case-control pairs. A subsequent replication study included 144 case-control pairs nested within the Melbourne Collaborative Cohort Study (MCCS). Plasma concentrations of vitamin B2, vitamin B6, folate, vitamin B12, methionine and homocysteine were measured in prediagnostic samples and evaluated with respe..
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Funding Acknowledgements
The World Cancer Research Fund (UK) supported the biochemical analyses for the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The funding organization had no role in design and conduct of the study, collection, management, analysis, or interpretation of the data, preparation, review, or approval of the manuscript. The work undertaken by DCM that was reported in this paper was done during the tenure of an International Agency for Research on Cancer (IARC)-Australia Postdoctoral Fellowship from the International Agency for Research on Cancer, supported by the Cancer Council Australia. Dr. Ueland reports that he is a member of the steering board of the nonprofit Foundation to Promote Research Into Functional Vitamin B12 Deficiency. The EPIC study has been supported by the Europe Against Cancer Program of the European Commission (SANCO); Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, German Federal Ministry of Education and Research; Danish Cancer Society; Health Research Fund (FIS) of the Spanish Ministry of Health, Spanish Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra; Catalan Institute of Oncology, Spain; the ISCIII of the Spanish Ministry of Health (RETICC DR06/0020); Cancer Research UK; Medical Research Council, UK; Greek Ministry of Health; Stavros Niarchos Foundation; Hellenic Health Foundation; Italian Association for Research on Cancer (AIRC); Italian National Research Council, Fondazione-Istituto Banco Napoli, Italy; Associazione Italiana per la Ricerca sul Cancro-AIRC-Milan; Compagnia di San Paolo; Dutch Ministry of Public Health, Welfare and Sports; World Cancer Research Fund; Swedish Cancer Society; Swedish Scientific Council; Regional Government of Vasterbotten, Sweden; NordForsk (Centre of excellence programme HELGA), Norway; French League against Cancer (LNCC), France; National Institute for Health and Medical Research (INSERM), France; Mutuelle Generale de l'Education Nationale (MGEN), France; 3M Co, France; Gustave Roussy Institute (IGR), France; and General Councils of France.