The effects of SIFT on the reproducibility and biological accuracy of the structural connectome

Abstract

Diffusion MRI streamlines tractography is increasingly being used to characterise and assess the structural connectome of the human brain. However, issues pertaining to quantification of structural connectivity using streamlines reconstructions are well-established in the field, and therefore the validity of any conclusions that may be drawn from these analyses remains ambiguous. We recently proposed a post-processing method entitled "SIFT: Spherical-deconvolution Informed Filtering of Tractograms" as a mechanism for reducing the biases in quantitative measures of connectivity introduced by the streamlines reconstruction method. Here, we demonstrate the advantage of this approach in the cont..