Journal article
Matching for MHC haplotypes results in improved survival following unrelated bone marrow transplantation
GK Tay, CS Witt, FT Christiansen, D Charron, D Baker, R Herrmann, LK Smith, D Diepeveen, S Mallal, J McCluskey, S Lester, P Loiseau, H Teisserenc, J Chapman, B Tait, RL Dawkins
Bone Marrow Transplantation | STOCKTON PRESS | Published : 1995
Abstract
Unrelated bone marrow donor-recipient pairs were assessed retrospectively for matching of the HLA-B,-C region (beta-block) and HLA-DR,-DQ region (delta block) of the major histocompatibility complex (MHC) using a new DNA-based method referred to as MHC-block typing. The method utilises non-HLA DNA polymorphisms in the MHC as markers of blocks of ancestral haplotypes. Kaplan-Meier analysis of recipients who were matched at both the beta- and delta-blocks revealed a 6 month survival of 54%. Survival was better than for patients who were matched only by conventional criteria, including SSO-typing for class II.