Journal article
Strategies for designing and monitoring malaria vaccines targeting diverse antigens
AE Barry, A Arnott
Frontiers in Immunology | Published : 2014
Abstract
After more than 50 years of intensive research and development, only one malaria vaccine candidate, "RTS,S," has progressed to Phase 3 clinical trials. Despite only partial efficacy, this candidate is now forecast to become the first licensed malaria vaccine. Hence, more efficacious second-generation malaria vaccines that can significantly reduce transmission are urgently needed. This review will focus on a major obstacle hindering development of effective malaria vaccines: parasite antigenic diversity. Despite extensive genetic diversity in leading candidate antigens, vaccines have been and continue to be formulated using recombinant antigens representing only one or two strains. These vacc..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors are grateful to all of our colleagues and mentors who have contributed to discussions about the concepts outlined in this review over the last several years, in particular, J. Reeder, J. Beeson, M. Good, and I. Mueller. The authors' research is supported by Project Grants awarded to Alyssa E. Barry by the National Health and Medical Research Council of Australia (No. 488211, 1005653 and 1003825). The work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS.