Molecular diagnostics and therapeutics for ectopic pregnancy
Stephen Tong, Monika M Skubisz, Andrew W Horne
MOLECULAR HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2015
Ectopic pregnancies are a serious gynaecological emergency that can be fatal. As such, prompt diagnosis and safe timely treatment is essential. Here, we review the literature on the development of molecularly targeted diagnostics and therapeutics for ectopic pregnancy. A blood-based biomarker that accurately identifies an ectopic pregnancy could be used to offer early diagnostic certainty in cases where ultrasound cannot determine the location of the embryo ('a pregnancy of unknown location'). Molecules examined so far can be broadly grouped into biological themes of relevance to reproduction: (i) Fallopian tube (dys)function, (ii) embryo/trophoblast growth, (iii) corpus luteum function, (iv..View full abstract
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Awarded by National Health and Medical Research Council
Awarded by Medical Research Council
This work was supported by the National Health and Medical Research Council (grant numbers 1008276, 1050765).