Recanalization and Clinical Outcome of Occlusion Sites at Baseline CT Angiography in the Interventional Management of Stroke III Trial
Andrew M Demchuk, Mayank Goyal, Sharon D Yeatts, Janice Carrozzella, Lydia D Foster, Emmad Qazi, Michael D Hill, Tudor G Jovin, Marc Ribo, Bernard Yan, Osama O Zaidat, Donald Frei, Ruediger von Kummer, Kevin M Cockroft, Pooja Khatri, David S Liebeskind, Thomas A Tomsick, Yuko Y Palesch, Joseph P Broderick
RADIOLOGY | RADIOLOGICAL SOC NORTH AMERICA | Published : 2014
PURPOSE: To use baseline computed tomographic (CT) angiography to analyze imaging and clinical end points in an Interventional Management of Stroke III cohort to identify patients who would benefit from endovascular stroke therapy. MATERIALS AND METHODS: The primary clinical end point was 90-day dichotomized modified Rankin Scale (mRS) score. Secondary end points were 90-day mRS score distribution and 24-hour recanalization. Prespecified subgroup was baseline proximal occlusions (internal carotid, M1, or basilar arteries). Exploratory analyses were subsets with any occlusion and specific sites of occlusion (two-sided α = .01). RESULTS: Of 656 subjects, 306 (47%) underwent baseline CT angiogr..View full abstract
Awarded by National Institutes of Health
Awarded by Alberta Innovates
This research was supported by the National Institutes of Health (grants UC U01NS052220, MUSC U01NS054630, and U01NS077304).