Journal article

Anti-caries effect of CPP-ACP in irradiated nasopharyngeal carcinoma patients

Christina PC Sim, Joseph Wee, Ying Xu, Yin-Bun Cheung, Yoke-Lim Soong, David J Manton



OBJECTIVE: The aim of this study was to determine the effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on caries progression in irradiated nasopharyngeal carcinoma (NPC) patients. METHODS: Twenty-one males and three females (median age, 50 years) were randomized into two groups before radiotherapy. Subjects had at least eight teeth after oral health clearance. The test group used 0.4 % stannous fluoride gel and a crème containing 10 % CPP-ACP daily; the control group used a similar crème without CPP-ACP and otherwise identical care. Subjects applied the crème three times daily and fluoride gel once daily. Caries status, saliva and plaque parameters were measured pre-radi..

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University of Melbourne Researchers


Funding Acknowledgements

The contributions by Drs KW Fong, T Tan and SL Cheah from the National Cancer Centre Singapore and Drs JR Yang, MM Lim, S Ashok and J Lu from the National Dental Centre Singapore are highly acknowledged. Likewise, the support and encouragement of Clinical Assoc Prof KH Teoh at the National Dental Centre Singapore is appreciated. This research was supported by the National Dental Centre of Singapore Research Fund/National Medical Research Council Enabling Grant. GC Asia (Tokyo, Japan) provided the test products. The funding body and GC Asia had no involvement in the study design, collection, analysis and interpretation of data, and the writing and submission of the manuscript.