Journal article
Regional Brain Morphometric Characteristics of Nonsyndromic Cleft Lip and Palate
CL Adamson, VA Anderson, P Nopoulos, ML Seal, AC Da Costa
Developmental Neuroscience | Published : 2014
DOI: 10.1159/000365389
Abstract
Nonsyndromic cleft lip and palate (NSCLP) encompasses a group of orofacial abnormalities. Emerging evidence has revealed the presence of structural brain abnormalities in affected individuals. Previous studies have performed structure-based volumetric analysis of the brain assessing gross lobular subdivisions of the cerebral cortex and white matter which may have only vague relationships to the functional subregions implicated in behavioral and cognitive deficits observed in NSCLP patients. High-resolution magnetic resonance imaging structural data were acquired to provide a detailed characterization of the brain with respect to both regional cortical volume and thickness in 26 children with..
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Awarded by National Health and Medical Research Council Health Professional Research Fellowship
Funding Acknowledgements
This research was conducted within the Developmental Imaging research group, Murdoch Childrens Research Institute at the Children's MRI Centre, Royal Children's Hospital, Melbourne, Vic. It was supported by the Murdoch Childrens Research Institute, Royal Children's Hospital, The University of Melbourne Department of Paediatrics and the Victorian Government's Operational Infrastructure Support Program. This research was funded by a National Health and Medical Research Council Health Professional Research Fellowship (No. 436999) for Dr. Annette C. Da Costa. We thank the participants and their families for their involvement in this study.