Journal article

Association Between Molecular Subtypes of Colorectal Cancer and Patient Survival

Amanda I Phipps, Paul J Limburg, John A Baron, Andrea N Burnett-Hartman, Daniel J Weisenberger, Peter W Laird, Frank A Sinicrope, Christophe Rosty, Daniel D Buchanan, John D Potter, Polly A Newcomb

Gastroenterology | W B SAUNDERS CO-ELSEVIER INC | Published : 2015

Abstract

BACKGROUND AND AIMS: Colorectal cancer (CRC) is a heterogeneous disease that can develop via several pathways. Different CRC subtypes, identified based on tumor markers, have been proposed to reflect these pathways. We evaluated the significance of these previously proposed classifications to survival. METHODS: Participants in the population-based Seattle Colon Cancer Family Registry were diagnosed with invasive CRC from 1998 through 2007 in western Washington State (N = 2706), and followed for survival through 2012. Tumor samples were collected from 2050 participants and classified into 5 subtypes based on combinations of tumor markers: type 1 (microsatellite instability [MSI]-high, CpG isl..

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Grants

Awarded by National Cancer Institute at the National Institutes of Health


Awarded by National Center for Advancing Translational Science at the National Institutes of Health


Awarded by NATIONAL CANCER INSTITUTE


Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES


Funding Acknowledgements

This work was supported by the National Cancer Institute at the National Institutes of Health (K07CA172298 to A.I.P., U01CA74794, R01CA076366, R01CA118699, R01CA107333, K05CA142885 to P.A.N.), the National Center for Advancing Translational Science at the National Institutes of Health (KL2TR000421 to A.N.B.-H.), and through cooperative agreements with members of the Colon Cancer Family Registry and Principal Investigators. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The sponsors had no role in the design and conduct of the study; no role in the collection, management, analysis, and interpretation of data; no role in preparation, review, or approval of the manuscript; and no role in the decision to submit the manuscript for publication.