Journal article
Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer
RE Neale, PJ Clark, J Fawcett, L Fritschi, BN Nagler, HA Risch, RJ Walters, WJ Crawford, PM Webb, DC Whiteman, DD Buchanan
Cancer Epidemiology | ELSEVIER SCI LTD | Published : 2014
Abstract
Pancreatic cancer is a leading cause of cancer-related deaths worldwide. Methylation of DNA may influence risk or be a marker of early disease. The aim of this study was to measure the association between methylation of three DNA repetitive elements in white blood cell (WBC) DNA and pancreatic cancer. DNA from WBCs of pancreatic cancer cases (n = 559) and healthy unrelated controls (n = 603) were tested for methylation of the LINE-1, Alu and Sat2 DNA repetitive elements using MethyLight quantitative PCR assays. Odds ratios (ORs) and 95% confidence intervals (95%CI) between both continuous measures of percent of methylated sample compared to a reference (PMR) or quintiles of PMR and pancreati..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by funding obtained by the Rio Tinto Ride to Conquer Cancer (QIMR Berghofer Medical Research Institute) and a National Health and Medical Research Council project grant (Grant number 442302). R.E. Neale, L. Fritschi, P.M. Webb and D.C. Whiteman are supported by NHMRC fellowships. We would like to acknowledge all the participants who took part in this research.