Journal article

Relationship between amygdala volume and emotion recognition in adolescents at ultra-high risk for psychosis

Cali F Bartholomeusz, Sarah L Whittle, Eleanor Pilioussis, Kelly Allott, Simon Rice, Miriam R Schaefer, Christos Pantelis, G Paul Amminger

PSYCHIATRY RESEARCH-NEUROIMAGING | ELSEVIER IRELAND LTD | Published : 2014

Abstract

Amygdala volume has been proposed as a neural risk biomarker for psychotic illness, but findings in the ultra-high risk for psychosis (UHR) population have been somewhat inconsistent, which may be related to underlying social cognitive abilities. The current study investigated whether amygdala volumes were related to emotion-recognition impairments in UHR individuals, and whether volumes differed by sex. Secondary aims were to assess whether (a) emotion-recognition performance was associated with interhemispheric amygdala volume asymmetry and (b) amgydala volume and volume asymmetry acted as a mediator between emotion-recognition and outcome measures. The amygdala was manually delineated fro..

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Grants

Awarded by Stanley Medical Research Institute


Awarded by National Health and Medical Research Council (NHMRC) of Australia Australian-based Clinical Research Fellowships


Awarded by NHMRC Career Development Fellowship


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by NHMRC


Funding Acknowledgements

This work was supported by the Stanley Medical Research Institute (03T-315 to G.R.A.), two National Health and Medical Research Council (NHMRC) of Australia Australian-based Clinical Research Fellowships (567042 to C.B., 628884 to K.A.), a NHMRC Career Development Fellowship (1007716 to S.L.W.), aNHMRC Senior Principal Research Fellowship (628386 to C.P.), a Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award(C.P.), and a NHMRC Grant (566529) to G.P.A. Neuroimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory at the Melbourne Neuropsychiatry Centre and supported by Neurosciences Victoria. The authors thank the Diagnose Zentrum Urania diagnostic centre and the Royal Melbourne Hospital for support in acquiring the neuroimaging data.