Conference Proceedings
Alzheimer's disease detection using 11C-PiB with improved partial volume effect correction
P Raniga, P Bourgeat, J Fripp, O Acosta, S Ourselin, C Rowe, VL Villemagne, O Salvado
Progress in Biomedical Optics and Imaging Proceedings of SPIE | Published : 2009
DOI: 10.1117/12.813501
Abstract
Despite the increasing use of 11C-PiB in research into Alzheimer's disease (AD), there are few standardized analysis procedures that have been reported or published. This is especially true with regards to partial volume effects (PVE) and partial volume correction. Due to the nature of PET physics and acquisition, PET images exhibit relatively low spatial resolution compared to other modalities, resulting in bias of quantitative results. Although previous studies have applied PVE correction techniques on 11C-PiB data, the results have not been quantitatively evaluated and compared against uncorrected data. The aim of this study is threefold. Firstly, a realistic synthetic phantom was created..
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