Journal article
Apparent diffusion coefficient threshold for delineation of ischemic core
A Purushotham, BCV Campbell, M Straka, M Mlynash, JM Olivot, R Bammer, SM Kemp, GW Albers, MG Lansberg
International Journal of Stroke | WILEY-BLACKWELL | Published : 2015
DOI: 10.1111/ijs.12068
Abstract
MRI-based selection of patients for acute stroke interventions requires rapid accurate estimation of the infarct core on diffusion-weighted MRI. Typically used manual methods to delineate restricted diffusion lesions are subjective and time consuming. These limitations would be overcome by a fully automated method that can rapidly and objectively delineate the ischemic core. An automated method would require predefined criteria to identify the ischemic core. Aim: The aim of this study is to determine apparent diffusion coefficient-based criteria that can be implemented in a fully automated software solution for identification of the ischemic core. Methods: Imaging data from patients enrolled..
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Awarded by National Institute of Biomedical Imaging and Bioengineering
Funding Acknowledgements
The funding for this study was provided by National Institutes of Health (NIH) grants R01 NS39325 (GWA), R01 EB002711 (RB), K24 NS044848 (GWA), and K23 NS051372 (MGL). tPA was supplied at no charge by Genentech (United States and Canada sites) and Boehringer Ingelheim (Belgium site). Neither Genentech, Boehringer Ingelheim nor the NIH played a role in the design or conduct of the study, data collection, management, analysis, or interpretation, or preparation, review or approval of the manuscript.