Vascularisation to improve translational potential of tissue engineering systems for cardiac repair
Rodney J Dilley, Wayne A Morrison
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2014
Cardiac tissue engineering is developing as an alternative approach to heart transplantation for treating heart failure. Shortage of organ donors and complications arising after orthotopic transplant remain major challenges to the modern field of heart transplantation. Engineering functional myocardium de novo requires an abundant source of cardiomyocytes, a biocompatible scaffold material and a functional vasculature to sustain the high metabolism of the construct. Progress has been made on several fronts, with cardiac cell biology, stem cells and biomaterials research particularly promising for cardiac tissue engineering, however currently employed strategies for vascularisation have lagge..View full abstract
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Awarded by National Health and Medical Research Council of Australia (NHMRC)
These studies were supported by grants from National Health and Medical Research Council of Australia (NHMRC 1024817), the Tony and Gwyneth Lennon Foundation, and the Victorian State Government's Department of Innovation, Industry and Regional Development's Operational Infrastructure Support Program.