Wongabel Rhabdovirus Accessory Protein U3 Targets the SWI/SNF Chromatin Remodeling Complex
D Albert Joubert, Julio Rodriguez-Andres, Paul Monaghan, Michelle Cummins, William J McKinstry, Prasad N Paradkar, Gregory W Moseley, Peter J Walker
JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2015
UNLABELLED: Wongabel virus (WONV) is an arthropod-borne rhabdovirus that infects birds. It is one of the growing array of rhabdoviruses with complex genomes that encode multiple accessory proteins of unknown function. In addition to the five canonical rhabdovirus structural protein genes (N, P, M, G, and L), the 13.2-kb negative-sense single-stranded RNA (ssRNA) WONV genome contains five uncharacterized accessory genes, one overlapping the N gene (Nx or U4), three located between the P and M genes (U1 to U3), and a fifth one overlapping the G gene (Gx or U5). Here we show that WONV U3 is expressed during infection in insect and mammalian cells and is required for efficient viral replication...View full abstract
Awarded by National Health and Medical Research Council of Australia
The study was supported in part by a grant from the National Health and Medical Research Council of Australia (grant 1003244) to G.W.M.