Journal article

Racial and ethnic differences in epilepsy classification among probands in the Epilepsy Phenome/Genome Project (EPGP)

Daniel Friedman, Robyn Fahlstrom, Bassel Abou-Khalil, Brian Alldredge, Jocelyn Bautista, Sam Berkovic, Judith Bluvstein, Alex Boro, Gregory Cascino, Damian Consalvo, Sabrina Cristofaro, Patricia Crumrine, Orrin Devinsky, Dennis Dlugos, Michael Epstein, Miguel Fiol, Nathan Fountain, Kristen Fox, Jacquelin French, Catharine Fryer Karn Show all

EPILEPSY RESEARCH | ELSEVIER SCIENCE BV | Published : 2013

Abstract

Little is known about the ethnic and racial differences in the prevalence of generalized and focal epilepsy among patients with non-acquired epilepsies. In this study, we examined epilepsy classification and race/ethnicity in 813 probands from sibling or parent-child pairs with epilepsy enrolled in the Epilepsy Genome/Phenome Project (EPGP). Subjects were classified as generalized epilepsy (GE), non-acquired focal epilepsy (NAFE), mixed epilepsy syndrome (both generalized and focal), and unclassifiable, based on consensus review of semiology and available clinical, electrophysiology, and neuroimaging data. In this cohort, 628 (77.2%) subjects identified exclusively as Caucasian/white and 65 ..

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Grants

Awarded by NINDS


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

Supported by NINDS U01 NS 053998. We would like to acknowledge the recruitment contributions of the EPGP Community Referral Network (CRN). The CRN consists of healthcare professionals not paid by the EPGP grant who refer eligible families to EPGP. A list of individual contributors can be found at www.epgp.org. In addition, we would like to acknowledge the efforts of the clinical coordinators, the site principal investigators, neurologists, and support staff at our EPGP clinical centers who have contributed significant effort into recruitment, data acquisition and storage, and extensive phenotyping. Finally, we extend our sincere appreciation to the participants with epilepsy and their families who have contributed to this research effort.