Journal article

The Hippo Pathway Regulates Hematopoiesis in Drosophila melanogaster

Claire C Milton, Felix A Grusche, Joffrey L Degoutin, Eefang Yu, Qi Dai, Eric C Lai, Kieran F Harvey

Current Biology | CELL PRESS | Published : 2014


The Salvador-Warts-Hippo (Hippo) pathway is an evolutionarily conserved regulator of organ growth and cell fate. It performs these functions in epithelial and neural tissues of both insects and mammals, as well as in mammalian organs such as the liver and heart. Despite rapid advances in Hippo pathway research, a definitive role for this pathway in hematopoiesis has remained enigmatic. The hematopoietic compartments of Drosophila melanogaster and mammals possess several conserved features. D. melanogaster possess three types of hematopoietic cells that most closely resemble mammalian myeloid cells: plasmatocytes (macrophage-like cells), crystal cells (involved in wound healing), and lamelloc..

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Awarded by NIH


Funding Acknowledgements

We thank M. Crozatier for comments on an earlier version of this manuscript and I. Ando, E. Bach, S. Bray, C. Desplan, R. Fehon, K. Guss, I. Hariharan, K. Irvine, J. Jiang, D. Jukam, L. Madden, D. Pan, L. Waltzer, T. Xu, the Developmental Studies Hybridoma Bank, the Australian D. melanogaster Research Support Facility (, the Vienna D. melanogaster RNAi Centre, and the Bloomington Stock Centre for fly stocks, antibodies, and plasmids. K.F.H is a Sylvia and Charles Viertel Senior Medical Research Fellow. F.G was a Cancer Council Victoria Postdoctoral Research Fellow. This work was supported by a Project Grant from the National Health and Medical Research Council of Australia. Q.D. was supported by a fellowship from the Swedish Research Council. Work in E.C.L.'s group was supported by NIH grants R01NS083833 and R01NS074037.