Journal article

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T-reg cells and macrophages in adipose tissue

Lydia Lynch, Xavier Michelet, Sai Zhang, Patrick J Brennan, Ashley Moseman, Chantel Lester, Gurdyal Besra, Emilie E Vomhof-Dekrey, Mike Tighe, Hui-Fern Koay, Dale I Godfrey, Elizabeth A Leadbetter, Derek B Sant'Angelo, Ulrich von Andrian, Michael B Brenner

Nature Immunology | NATURE PUBLISHING GROUP | Published : 2015

Grants

Awarded by US National Institutes of Health


Awarded by American Diabetes Association


Awarded by National Health and Medical Research Council of Australia


Awarded by National Institute of Allergy and Infectious Diseases of the US National Institutes of Health


Awarded by Robert Wood Johnson Foundation


Awarded by Medical Research Council


Funding Acknowledgements

We thank M. Exley (Harvard Medical School) for Cd1d<SUP>-/-</SUP> mice; P.P. Pandolfi (Harvard Medical School) for the use of Plzf<SUP>-/-</SUP> mice; A. Rudensky (Memorial Sloan-Kettering Cancer Center) for Foxp3-GFP mice; E. Pamer (Memorial Sloan-Kettering Cancer Center) for the pLD53 SC-AB vector system; and K. Rothamel (Harvard Medical School) and the US National Institutes of Health Tetramer Core for mouse CD1d-PBS57 tetramers; and E. Lynch for assistance with imaging. This work benefited from public data generated by the Immunological Genome Project. Supported by Marie Curie Actions (L.L.), the US National Institutes of Health (AI063428, AI028973 and DK057521 to M.B.B.; and T32 A1049823 to E.E.V.-D.), the American Diabetes Association (7-12-IN-07 to M.B.B.), the American Academy of Allergy, Asthma and Immunology ARTrust (P.J.B.), the Trudeau Institute (M.T., E.E.V.-D. and E.A.L.), The National Health and Medical Research Council of Australia (1013667 to D.I.G. and H.-F.K.; and a1020770 to D.I.G.), the National Institute of Allergy and Infectious Diseases of the US National Institutes of Health (R01 AI083988 and AI059739 to D.B.S.) and the Robert Wood Johnson Foundation (67038 to the Child Health Institute of New Jersey, support for D.B.S.).