Fabrication of chiral stationary phases via continuous assembly of polymers for resolution of enantiomers by liquid chromatography

SN Guntari; E Nam; NN Pranata; K Chia; EHH Wong; A Blencowe; TK Goh; F Caruso; GG Qiao

Journal article

Fabrication of chiral stationary phases via continuous assembly of polymers for resolution of enantiomers by liquid chromatography

SN Guntari, E Nam, NN Pranata, K Chia, EHH Wong, A Blencowe, TK Goh, F Caruso, GG Qiao

Macromolecular Materials and Engineering | Published : 2014

DOI: 10.1002/mame.201400103

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Abstract

Precise stereochemical determination of chiral molecules is highly important, especially in the pharmaceutical industry where one enantiomer may have a therapeutic effect while the other has detrimental effects. Herein, the continuous assembly of polymers (CAP) mediated via ringopening metathesis polymerization (ROMP) is used to fabricate immobilized-type chiral stationary phases (CSPs) - as cross-linked thin films on solid supports - for enantiomeric separation. Optically active polysaccharides (chitosan and amylose) with aromatic substituents were pre-functionalized with pendent norbornene groups and subsequently employed as macrocross-linkers in the CAPROMP process, building cross-linked ..

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University of Melbourne Researchers

Frank Caruso Author

Greg Qiao Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

The authors acknowledge the Australian Research Council under the Australian Laureate Fellowship (FL120100030, F.C.), Future Fellowship (FT110100411, G. G. Q.), and Discovery Project (DP1094147 and DP130101846, F. C., G. G. Q.) schemes for financial support of this work.