Journal article
Polymorphisms in the APOE gene and the location of retinal fluid in eyes with neovascular age-related macular degeneration
SS Wickremasinghe, SS Sandhu, FM Amirul-Islam, F Abedi, AJ Richardson, PN Baird, RH Guymer
Retina | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
Abstract
BACKGROUND: Previous reports suggest that the outcome of age-related macular degeneration treatment is dependent on variants in the apolipoprotein E (APOE) gene. We wish to establish if variants in this gene are associated with anatomical location of fluid within the macula on optical coherence tomography imaging before and after three anti-vascular endothelial growth factor treatments. METHODS: Patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration were prospectively enrolled and monitored over a 12-month period. Main outcome measures were logMAR best-corrected visual acuity and correlation of qualitative optical coherence tomography features (int..
View full abstractGrants
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC-Clinical Research Excellence grant
Awarded by NHMRC practitioner fellowship
Awarded by NHMRC Senior Research Fellowship
Funding Acknowledgements
Supported by National Health and Medical Research Council (NHMRC) through project grant 590205 and 1008979, an NHMRC-Clinical Research Excellence grant 529923-Translational Clinical Research in Major Eye Diseases, NHMRC practitioner fellowship 529905 (R.H.G.), and NHMRC Senior Research Fellowship 1028444 (P.N.B.). The Centre for Eye Research Australia (CERA) receives Operational Infrastructure Support from the Victorian Government.