Ingestion of oats and barley in patients with celiac disease mobilizescross-reactive T cells activated by avenin peptides andimmuno-dominant hordein peptides

Abstract

Celiac disease (CD) is a common CD4+ T cell mediated enteropathy driven by gluten in wheat, rye, and barley. Whilst clinical feeding studies generally support the safety of oats ingestion in CD, the avenin protein from oats can stimulate intestinal gluten-reactive T cells isolated from some CD patients invitro. Our objective was to establish whether ingestion of oats or other grains toxic in CD stimulate an avenin-specific T cell response invivo.We fed participants a meal of oats (100g/day over 3 days) to measure the invivo polyclonal avenin-specific T cell responses to peptides contained within comprehensive avenin peptide libraries in 73 HLA-DQ2.5+ CD patients. Grain cross-reactivity was i..