Cortico-limbic network abnormalities in individuals with current and past major depressive disorder

P Klauser; A Fornito; V Lorenzetti; CG Davey; DB Dwyer; NB Allen; M Yücel

Journal article

Cortico-limbic network abnormalities in individuals with current and past major depressive disorder

P Klauser, A Fornito, V Lorenzetti, CG Davey, DB Dwyer, NB Allen, M Yücel

Journal of Affective Disorders | Published : 2015

DOI: 10.1016/j.jad.2014.10.041

Abstract

Background Brain abnormalities in fronto-temporal structures have been implicated in major depressive disorder (MDD). This study aims to identify their anatomical distribution and their relation to the time course of the disease.Methods A whole-brain voxel based morphometry analysis was conducted to assess gray and white matter alterations in 56 participants with a lifetime history of MDD, including currently depressed (cMDD) and remitted patients (rMDD), and 33 matched healthy controls (HC).Results Compared to HC, MDD participants showed increased white matter volume (WMV) in the uncinate fasciculus (UF) and decreased gray matter density (GMD) on the ventromedial prefrontal cortex (vmPFC). ..

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University of Melbourne Researchers

Related Projects (1)

The self and social engagement in young people with depression and at high risk of depression.

Grants

Awarded by Australian Research Council

Funding Acknowledgements

Paul Klauser was supported by the Swiss National Science Foundation and the Swiss Society for Medicine and Biology Scholarships (ID: 148384). Alex Forinto was supported by an National Health and Medical Research Council (NHMRC) Project Grant (ID: 1050504) and Australian Research Council (ARC) Future Fellowship (ID: FT130100589). Valentina Lorenzetti was supported by the Monash Bridging Postdoctoral Fellowship. Christopher Davey was supported by an NHMRC Career Development Fellowship (ID: 628922). Murat Yucel was supported by an NHMRC Fellowship Grant (ID: 1021973).