Comparative effectiveness of glatiramer acetate and interferon beta formulations in relapsing-remitting multiple sclerosis

Tomas Kalincik; Vilija Jokubaitis; Guillermo Izquierdo; Pierre Duquette; Marc Girard; Pierre Grammond; Alessandra Lugaresi; Celia Oreja-Guevara; Roberto Bergamaschi; Raymond Hupperts; Francois Grand'Maison; Eugenio Pucci; Vincent Van Pesch; Cavit Boz; Gerardo Iuliano; Ricardo Fernandez-Bolanos; Shlomo Flechter; Daniele Spitaleri; Edgardo Cristiano; Freek Verheul; Jeannette Lechner-Scott; Maria Pia Amato; Jose Antonio Cabrera-Gomez; Maria Laura Saladino; Mark Slee; Fraser Moore; Orla Gray; Mark Paine; Michael Barnett; Eva Havrdova; Dana Horakova; Timothy Spelman; Maria Trojano; Helmut Butzkueven

Journal article

Comparative effectiveness of glatiramer acetate and interferon beta formulations in relapsing-remitting multiple sclerosis

Tomas Kalincik, Vilija Jokubaitis, Guillermo Izquierdo, Pierre Duquette, Marc Girard, Pierre Grammond, Alessandra Lugaresi, Celia Oreja-Guevara, Roberto Bergamaschi, Raymond Hupperts, Francois Grand'Maison, Eugenio Pucci, Vincent Van Pesch, Cavit Boz, Gerardo Iuliano, Ricardo Fernandez-Bolanos, Shlomo Flechter, Daniele Spitaleri, Edgardo Cristiano, Freek Verheul Show all

MULTIPLE SCLEROSIS JOURNAL | SAGE PUBLICATIONS LTD | Published : 2015

DOI: 10.1177/1352458514559865

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Abstract

BACKGROUND: The results of head-to-head comparisons of injectable immunomodulators (interferon β, glatiramer acetate) have been inconclusive and a comprehensive analysis of their effectiveness is needed. OBJECTIVE: We aimed to compare, in a real-world setting, relapse and disability outcomes among patients with multiple sclerosis (MS) treated with injectable immunomodulators. METHODS: Pairwise analysis of the international MSBase registry data was conducted using propensity-score matching. The four injectable immunomodulators were compared in six head-to-head analyses of relapse and disability outcomes using paired mixed models or frailty proportional hazards models adjusted for magnetic res..

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University of Melbourne Researchers

Timothy Spelman Author Surgery - St Vincent's Hospital

John King Author Medicine - Royal Melbourne Hospital

Helmut Butzkueven Author Medicine - Royal Melbourne Hospital

Tomas Kalincik Author Medicine - Royal Melbourne Hospital

Anneke van der Walt Author Medicine - Royal Melbourne Hospital

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Grants

Awarded by Multiple Sclerosis Research Australia Postdoctoral Fellowship

Awarded by NHMRC Early Career Award

Awarded by NHMRC

Awarded by NHMRC Centre for Research Excellence

Funding Acknowledgements

The work was supported by the Multiple Sclerosis Research Australia Postdoctoral Fellowship [11-054] and NHMRC Early Career Award (Clinical) to TK [1071124], NHMRC Career Development Award (Clinical) to HB [628856], NHMRC Project Grant [1032484], NHMRC Centre for Research Excellence [1001216] and the MSBase Foundation. The MSBase Foundation is a not-for-profit organization that receives support from Merck Serono, Biogen Idec, Novartis Pharma, Bayer Schering, Sanofi-Aventis and BioCSL. The study was conducted separately and apart from the guidance of the sponsors. TK had full access to all the data and takes responsibility for integrity of the data and accuracy of the data analysis.