Journal article
Repair mechanisms help glioblastoma resist treatment
RJ Atkins, W Ng, SS Stylli, CM Hovens, AH Kaye
Journal of Clinical Neuroscience | Published : 2015
Abstract
Glioblastoma multiforme (GBM) is a malignant and incurable glial brain tumour. The current best treatment for GBM includes maximal safe surgical resection followed by concomitant radiotherapy and adjuvant temozolomide. Despite this, median survival is still only 14-16 months. Mechanisms that lead to chemo- and radio-resistance underpin treatment failure. Insights into the DNA repair mechanisms that permit resistance to chemoradiotherapy in GBM may help improve patient responses to currently available therapies.
Grants
Funding Acknowledgements
This study and/or its authors received funding from The Beaney Scholarship in Surgery, The University of Melbourne; Neurosurgical Society of Australasia Research Scholarships; the Royal Australasian College of Surgeons John Loewenthal Foundation for Surgery Scholarship; and the Brain Foundation of Australia Glioblastoma Award.