Journal article

Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders

Sandra Odebrecht Vargas Nunes, Marcia Regina Pizzo de Castro, Estefania Gastaldello Moreira, Roberta Losi Guembarovski, Decio Sabbatini Barbosa, Heber Odebrecht Vargas, Luiz Gustavo Piccoli de Melo, Chiara Cristina Bortolasci, Maria Angelica Ehara Watanabe, Seetal Dodd, Michael Berk, Michael Maes



There is evidence that genetic factors influence the probability of comorbidity of tobacco use disorder (TUD) with mood disorders. This study was carried out to examine whether both TUD and mood disorders are associated with genetic biomarkers particularly paraoxonase 1 (PON1) status, polymorphisms of glutathione S-transferases (GSTs), such as GSTM1 and GSTT1, and the STIn 2 polymorphism of the serotonin transporter. PON1 status (Q192R polymorphism and PON1 plasmatic activity), GSTM1, GSTT1, and STin.2 genotypes and alleles were assayed in 4 mutually exclusive study groups, i.e., comorbid mood disorder and TUD (n=95); TUD without mood disorders (n=90); mood disorders but no TUD (n=62); and c..

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Awarded by NHMRC Senior Principal Research Fellowship

Funding Acknowledgements

This study was supported by Health Sciences Graduation Program at Londrina State University, Parana., Brazil (UEL) and Fundacao Araucaria. MB is supported by a NHMRC Senior Principal Research Fellowship 1,059,660. MM is supported by a CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologia) PVE fellowship and the Health Sciences Graduate Program fellowship, Londrina State University (UEL).