Placental SEMA3B expression is not altered in severe early onset preeclampsia

TJ Kaitu'u-Lino; R Hastie; P Cannon; NK Binder; S Lee; O Stock; NJ Hannan; S Tong

Journal article

Placental SEMA3B expression is not altered in severe early onset preeclampsia

TJ Kaitu'u-Lino, R Hastie, P Cannon, NK Binder, S Lee, O Stock, NJ Hannan, S Tong

PLACENTA | W B SAUNDERS CO LTD | Published : 2014

DOI: 10.1016/j.placenta.2014.10.002

Abstract

Recent evidence suggests that Semaphorin 3B (SEMA3B) is upregulated in severe preeclampsia, and a major driver of cytotrophoblast aberrations in this disease. Here we independently assess whether SEMA3B expression is altered in a large cohort of severe early onset preeclamptic placentas. We demonstrate that SEMA3B relative mRNA expression and copy number are not changed in PE placentas. We confirm this at the protein level by western blot. Interestingly, exposure of term trophoblasts or explants to hypoxia induced a significant down regulation of SEMA3B mRNA, but a trend towards increased SEMA3B protein expression. We conclude that SEMA3B mRNA and protein is not altered in severe early onset..

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University of Melbourne Researchers

Tu'uhevaha Kaitu'u-Lino Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Roxanne Hastie Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Susan Walker Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Stephen Tong Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Ping Cannon Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

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Grants

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

The National Health and Medical Research Council of Australia provided salary (#1062418 to T.K, #628927 to N.H, #1050765 to S.T.) and Scholarship Support (#1055795 to O.S.)