Journal article
EGb761 provides a protective effect against Aβ1-42 oligomer-induced cell damage and blood-brain barrier disruption in an in vitro bEnd.3 endothelial model
WB Wan, L Cao, LM Liu, B Kalionis, C Chen, XT Tai, YM Li, S Xia
Plos One | Published : 2014
Abstract
Alzheimer's disease (AD) is the most common form of senile dementia which is characterized by abnormal amyloid beta (Ab) accumulation and deposition in brain parenchyma and cerebral capillaries, and leads to blood-brain barrier (BBB) disruption. Despite great progress in understanding the etiology of AD, the underlying pathogenic mechanism of BBB damage is still unclear, and no effective treatment has been devised. The standard Ginkgo biloba extract EGb761 has been widely used as a potential cognitive enhancer for the treatment of AD. However, the cellular mechanism underlying the effect remain to be clarified. In this study, we employed an immortalized endothelial cell line (bEnd.3) and inc..
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Awarded by National Natural Science Foundation of China
Awarded by Shanghai Committee of Science and Technology, China
Funding Acknowledgements
The authors gratefully acknowledge the financial support of this study by National Natural Science Foundation of China (Grant No. 81473739), and Shanghai Committee of Science and Technology, China (Grant No. 12401904500), YML received the funding, (http://www.nsfc.gov.cn/) and (http://www.stcsm.gov.cn/), respectively; by National Natural Science Foundation of China (Grant No. 31171129, Grant No. 81460748), SJX received the funding, (http://www.nsfc.gov.cn/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.