Olfactory identification deficits at identification as ultra-high risk for psychosis are associated with poor functional outcome
A Lin, WJ Brewer, AR Yung, B Nelson, C Pantelis, SJ Wood
SCHIZOPHRENIA RESEARCH | ELSEVIER | Published : 2015
BACKGROUND: We have previously reported that olfactory identification (OI) deficits are a promising premorbid marker of transition from ultra-high risk (UHR) to schizophrenia, but not to psychotic illness more generally. Whether this remains the case at longer follow-up, and whether there is decline in OI ability are unclear. METHOD: The University of Pennsylvania Smell Identification Test (UPSIT) was administered to 81 participants at baseline (identification of risk for psychosis) and 254 individuals at follow-up. Forty-nine participants underwent UPSIT assessment at both time points. UPSIT scores were investigated at an average of 7.08years after identification of risk in relation to tran..View full abstract
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Awarded by NHMRC Program
This work was supported by NHMRC Program Grants (# 350241 and 566529) and the Colonial Foundation, Australia. SJW and WJB were supported by the National Health and Medical Research Council (NHMRC) Career Development Awards. BN was supported by a Ronald Phillip Griffith Fellowship and a NARSAD Young Investigator Award. CP and ARY are the recipients of NHMRC Senior Principal and Senior Research Fellowships, respectively.