Journal article
Additive interactions between susceptibility single-nucleotide polymorphisms identified in genome-wide association studies and breast cancer risk factors in the breast and prostate cancer cohort consortium
AD Joshi, S Lindström, A Hüsing, M Barrdahl, TJ Van Der Weele, D Campa, F Canzian, MM Gaudet, JD Figueroa, L Baglietto, CD Berg, JE Buring, SJ Chanock, MD Chirlaque, W Ryan Diver, L Dossus, GG Giles, CA Haiman, SE Hankinson, BE Henderson Show all
American Journal of Epidemiology | Published : 2014
DOI: 10.1093/aje/kwu214
Abstract
Additive interactions can have public health and etiological implications but are infrequently reported. We assessed departures from additivity on the absolute risk scale between 9 established breast cancer risk factors and 23 susceptibility single-nucleotide polymorphisms (SNPs) identified from genome-wide association studies among 10,146 non-Hispanic white breast cancer cases and 12,760 controls within the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium. We estimated the relative excess risk due to interaction and its 95% confidence interval for each pairwise combination of SNPs and nongenetic risk factors using age-and cohort-adjusted logistic regression models. A..
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Awarded by National Institutes of Health
Funding Acknowledgements
This study was funded by the National Cancer Institute, US National Institutes of Health (grant CA148065 and cooperative agreements U01-CA98233 and U19-CA148065 to D.J.H., U01-CA98710 to M.J.T., U01-CA98216 to E. R. and R. K., and U01-CA98758 to B. E. H.) and the Intramural Research Program of the National Institutes of Health/National Cancer Institute, Division of Cancer Epidemiology and Genetics.