In situ formation of antimicrobial silver nanoparticles and the impregnation of hydrophobic polycaprolactone matrix for antimicrobial medical device applications
Phong A Tran, Dianna M Hocking, Andrea J O'Connor
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | ELSEVIER | Published : 2015
Bacterial infection associated with medical devices remains a challenge to modern medicine as more patients are being implanted with medical devices that provide surfaces and environment for bacteria colonization. In particular, bacteria are commonly found to adhere more preferably to hydrophobic materials and many of which are used to make medical devices. Bacteria are also becoming increasingly resistant to common antibiotic treatments as a result of misuse and abuse of antibiotics. There is an urgent need to find alternatives to antibiotics in the prevention and treatment of device-associated infections world-wide. Silver nanoparticles have emerged as a promising non-drug antimicrobial ag..View full abstract
Awarded by University of Melbourne
P.A.T. wishes to acknowledge the funding from his McKenzie Fellowship (the University of Melbourne (ISF2012)), and the Interdisciplinary Seed Funding (the Melbourne Materials Institute and the Bio21 Molecular Science & Biotechnology Institute, Australia).