Journal article
Hydrocortisone Prevents Immunosuppression by Interleukin-10 Natural Killer Cells After Trauma-Hemorrhage
A Roquilly, A Broquet, C Jacqueline, D Masson, JP Segain, C Braudeau, M Vourc h, J Caillon, F Altare, R Josien, C Retière, J Villadangos, K Asehnoune
Critical Care Medicine | Published : 2014
Abstract
© 2014 by the Society of Critical Care Medicine and Lippincott Williams & WilkinsOBJECTIVE:: Trauma induces a state of immunosuppression, which is responsible for the development of nosocomial infections. Hydrocortisone reduces the rate of pneumonia in patients with trauma. Because alterations of dendritic cells and natural killer cells play a central role in trauma-induced immunosuppression, we investigated whether hydrocortisone modulates the dendritic cell/natural killer cell cross talk in the context of posttraumatic pneumonia.DESIGN:: Experimental study.SETTINGS:: Research laboratory from an university hospital.SUBJECTS:: Bagg Albino/cJ mice (weight, 20–24 g).INTERVENTIONS:: First, in a..
View full abstractGrants
Funding Acknowledgements
[ "Dr. Roquilly was the recipient of funding from the Societe Francaise d'Anesthesie Reanimation, and from the Fondation des \"Gueules Cassees.\" Dr. Villadangos is funded by a grant from the National Health and Medical Research Council of Australia.", "Dr. Asehnoune served as board member for Astellas, received grant support from Astellas and Pfizer, lectured for B-Braun and Fresenius. Dr. Jacqueline served as board member for AstraZeneca and received support for article preparation from the Journal of Antimicrobial Chemotherapy. Dr. Caillon served as a board member for Novartis Laboratory. The remaining authors have disclosed that they do not have any potential conflicts of interest." ]